Identification of a novel e8/a4 BCR/ABL fusion transcript in a case of a transformed Sézary syndrome.
نویسندگان
چکیده
This report deals with a case of Sézary syndrome, a rare peripheral T-cell lymphoproliferative disorder, in which cytogenetic analysis performed during the disease transformation revealed the presence of a t(9;22) (q34;q11.2) translocation. Molecular analyses identified a new transcript, an e8a4 BCR-ABL fusion mRNA which could be responsible for the disease transformation.
منابع مشابه
BCR-ABL fusion genes and laboratory findings in patients with chronic myeloid leukemia in northeast Iran
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Background: The Philadelphia chromosome (Ph) characterized by t (9; 22) (q34; q11.2) is a reciprocal translocation giving rise to a chimeric BCR-ABL fusion gene. Incidence of Ph chromosome is over 98% in Patients with Chronic Myeloid Leukemia (CML) and around 20% in acute lymphoblastic leukemia (ALL). The finding of this fusion gene is essential for diagnosis of CML by detection of various fusi...
متن کاملفیوژن B3A2 شایع‌ترین نوع موتاسیون ABL-BCR در بیماران مبتلا به لوسمی میلوئیدی مزمن در استان لرستان
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ورودعنوان ژورنال:
- Haematologica
دوره 92 9 شماره
صفحات -
تاریخ انتشار 2007